The aim of this study was to determine the clinical, serological, and genetic features of anti-Jo-1 positive antisynthetase patients\nfollowed by aHungarian single centre to identify prognostic markers,which can predict disease phenotypes and disease progression.\nIt was a retrospective study using clinical database of 49 anti-Jo-1 positive patients. 100% of patients exhibited myositis, 73%\ninterstitial lung disease, 88% arthritis, 65% Raynaudâ??s phenomenon, 43% fever, 33% mechanicâ??s hand, and 12% dysphagia.We could\ndetect significant correlation between anti-Jo-1 titer and the CK and CRP levels at disease onset and during disease course. HLA\nDRB1*03 positivity was present in 68.96% of patients, where the CK level at diagnosis was significantly lower compared to the\nHLA DRB1*03 negative patients. HLA DQA1*0501-DQB1*0201 haplotype was found in 58.62% of patients, but no significant\ncorrelation was found regarding any clinical or laboratory features. Higher CRP, ESR level, RF positivity, and the presence of fever\nor vasculitic skin lesions at the time of diagnosis indicated a higher steroid demand and the administration of higher number of\nimmunosuppressants during the follow-up within anti-Jo-1 positive patients.The organ involvement of the disease was not different\nin HLA-DRB1*0301 positive or negative patients who were positive to the anti-Jo-1 antibody; however, initial CK level was lower\nin HLA-DRB1*0301 positive patients. Distinct laboratory and clinical parameters at diagnosis could be considered as prognostic\nmarkers.
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